Publications (PubMed)

(#Corresponding Author)

  • Kolakada D, Fu R, Biziaev N, Shuvalov A, Lore M, Campbell AE, Cortázar MA, Sajek MP, Hesselberth JR, Mukherjee N, Alkaeva E, Jagannathan S#. Peptidyl-tRNA hydrolysis rate influences the efficiency of nonsense-mediated mRNA decay. bioRxiv

  • Kolakada D, Campbell AE, Baquero Galvis L, Li Z, Lore M, and Jagannathan S#. A system of reporters for comparative investigation of EJC-independent and EJC-enhanced nonsense-mediated mRNA decay. Nucleic Acids Res. 2024; gkae121, doi: 10.1093/nar/gkae121. Link bioRxiv

  • Campbell AE, Arjomand J, King OD, Tawil R, Jagannathan S#. A Targeted Approach for Evaluating DUX4-Regulated Proteins as Potential Serum Biomarkers for Facioscapulohumeral Muscular Dystrophy Using Immunoassay Proteomics. J Neuromuscul Dis. 2023;10(6):1031-1040. doi: 10.3233/JND-221636. Link medRxiv

  • Hamm DC, Paatela EM, Bennett SR, Wong CJ, Campbell AE, Wladyka CL, Smith AA, Jagannathan S , Hsieh AC, Tapscott SJ.
    The transcription factor DUX4 orchestrates translational reprogramming by broadly suppressing translation efficiency and promoting expression of DUX4-induced mRNAs. PLoS Biol. 2023 Sep 25;21(9):e3002317. doi: 10.1371/journal.pbio.3002317. Link

  • Sherlock ME#, Baquero Galvis L, Vicens Q, Kieft JS, Jagannathan S#. Principles, Mechanisms, and Biological Implications of Translation Termination-Reinitiation. RNA. 2023 Jul;29(7):865-884. doi: 10.1261/rna.079375.122 Link (#Co-corresponding Author)

  • Muñoz O, Lore M, Jagannathan S#. The long and short of EJC-independent nonsense-mediated RNA decay. Biochem Soc Trans. 2023 Jun 28;51(3):1121-1129. doi: 10.1042/BST20221131. Link

  • Campbell AE, Dyle MC, Albanese R, Matheny T, Sudheendran K, Cortázar MA, Forman T, Fu R, Gillen AE, Caruthers MH, Floor SN, Calviello L, and Jagannathan S#. Compromised nonsense-mediated RNA decay results in truncated RNA-binding protein production upon DUX4 expression. Cell Reports 2023 Jun 27;42(6):112642; Link bioRxiv (*Equal Contribution)

  • Jagannathan S#. The evolution of DUX4 gene regulation and its implication for facioscapulohumeral muscular dystrophy. Biochim Biophys Acta Mol Basis Dis. 2022; May 1;1868(5):166367. Link

  • Jagannathan S* , de Greef JC*, Hayward LJ, Yokomori K, Gabellini D, Mul K, Sacconi S, Arjomand J, Kinoshita J, Harper SQ. Meeting report: the 2021 FSHD International Research Congress. Skeletal Muscle. 2022; Jan 17;12(1):1. Link

  • Child JR, Chen Q, Reid DW, Jagannathan S#, Nicchitta CV#. Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules. RNA. 2021; rna.078858.121. Link bioRxiv (#Co-corresponding Author)

  • Jagannathan S, Ramachandran S, Rissland OA. Slow down to catch up. Cell. 2019; 178(4):774-776 Link

  • Dyle MC, Kolakada D, Cortazar MA, Jagannathan S#. How to get away with nonsense: Mechanisms and consequences of escape from nonsense-mediated RNA decay. Wiley Interdiscip Rev RNA. 2019; 29:e1560 Link Readcube

  • Jagannathan S, Ogata Y, Gafken P, Tapscott SJ, Bradley RK. Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of FSHD. eLife. 2019; 8:e41740 Link  bioRxiv

  • Campbell AE, Shadle SC, Jagannathan S, Lim JW, Resnick R, Tawil R, van der Maarel SM, Tapscott SJ. NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins. eLife. 2018; 7:e31023 Link

  • Feng Q, Jagannathan S, Bradley RK. The RNA Surveillance Factor UPF1 Represses Myogenesis via Its E3 Ubiquitin Ligase Activity. Molecular cell. 2017; 67(2):239-251.e6. Link

  • Jagannathan S and Bradley RK. Congenital myotonic dystrophy-an RNA-mediated disease across a developmental continuum. Genes & development. 2017; 31(11):1067-1068. Link

  • Shadle SC, Zhong JW, Campbell AE, Conerly ML, Jagannathan S, Wong CJ, Morello TD, van der Maarel SM, Tapscott SJ. DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy. PLoS genetics. 2017; 13(3):e1006658. Link

  • Jagannathan S and Bradley R. Translational plasticity facilitates the accumulation of nonsense genetic variants in the human population. Genome Research. 2016 Sep 19. doi:10.1101/gr.205070.116. Link bioRxiv

  • Jagannathan S* , Shadle SC*, Resnick R, Snider L, Tawil RN, van der Maarel SM, Bradley RK and Tapscott SJ. Model systems of DUX4 expression recapitulate the transcriptional profile of FSHD cells. Hum Mol Genet. 2016 Aug 15. (*Equal Contribution) Link

  • Feng Q, Snider L, Jagannathan S, Tawil R, van der Maarel SM, Tapscott SJ, Bradley RK. A feedback loop between nonsense-mediated decay and the retrogene DUX4 in facioscapulohumeral muscular dystrophy. Elife. 2015 Jan 7;4. Link

  • Jagannathan S, Reid DW, Cox AH, Nicchitta CV. De novo translation initiation on membrane-bound ribosomes as a mechanism for localization of cytosolic protein mRNAs to the endoplasmic reticulum. RNA. 2014 Oct; 20(10):1489-98. Link

  • Jagannathan S* , Hsu JC*, Reid DW, Chen Q, Thompson WJ, Moseley AM, Nicchitta CV. Multifunctional roles for the protein translocation machinery in RNA anchoring to the endoplasmic reticulum. J Biol Chem. 2014 Sep 12; 289(37):25907-24. (*Equal Contribution) Link

  • Lacsina JR, Marks OA, Liu X, Reid DW, Jagannathan S, Nicchitta CV. Premature translational termination products are rapidly degraded substrates for MHC class I presentation. PLoS One. 2012; 7(12):e51968. Link

  • Chen Q, Jagannathan S*, Reid DW, Zheng T, Nicchitta CV. Hierarchical regulation of mRNA partitioning between the cytoplasm and the endoplasmic reticulum of mammalian cells. Mol Biol Cell. 2011 Jul 15; 22(14):2646-58. (*Equal Contribution) Link

  • Jagannathan S, Nwosu C, Nicchitta CV. Analyzing mRNA localization to the endoplasmic reticulum via cell fractionation. Methods Mol Biol. 2011; 714:301-21. Link